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Red Flags: When to Contact Your Provider Immediately Monitor for signs of thyroid imbalance during semaglutide treatment: unexplained fatigue, sudden weight gain despite compliance, cold intolerance, or dry skin may signal hypothyroidism requiring a lower levothyroxine dose

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One of the biggest reasons why your doctor wants to have a blood test for you before prescribing you semaglutide is to have a benchmark of your various blood markers from before you started the medication